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These results were positively reflected in the BCM-95 group’s serum inflammatory markers: CRP levels were reduced by 37.21%, and TNF-α levels were cut by 74.81%, indicating BCM-95 performed better than paracetamol.

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“We are learning more about the mechanisms behind curcumin’s anti-inflammatory effect which we believe is a result of its ability to inhibit pro-inflammatory signals, such as prostaglandins, leukotrienes, and cyclooxygenase-2. In addition, curcumin has been demonstrated to suppress several pro-inflammatory cytokines and mediators of their release, such as tumor necrosis factor-α (TNF-α), IL-1, IL-8, and nitric oxide synthase,”said Antony.

With the brevity of the study duration, the authors did hypothesize, however, that a longer-term supplementation regimen of lycopene could result in stronger antioxidant benefits for the isolated nutrient, in accordance with other studies that were carried out over a period of several weeks. Nonetheless, whole tomato contains chemical compounds that can enhance beneficial outcomes in synergy compared to a single compound, the authors said.