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Led by Shuba Singhal, PhD, this randomized, controlled clinical study was conducted at the Department of Orthopedics of Lok Nayak Jai Prakash Hospital/Maulana Azad Medical College, New Delhi. For the study, 193 patients diagnosed with osteoarthritis of the knee were randomized to receive either turmeric extract (BCM-95) as a 500 mg capsule two times daily, or a 650 mg tablet of paracetamol three times daily for six weeks.
In the randomized, double-blinded crossover study, 11 well-trained male athletes underwent three exhaustive exercise tests after a week of supplementation with a tomato powder, then a lycopene supplement, and then a placebo. Three blood samples (baseline, post-ingestion, and post-exercise) were taken for each of the supplements used, in order to evaluate total antioxidant capacity and variables of lipid peroxidation, such as malondialdehyde (MDA) and 8-isoprostane.
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