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Knee arthritis symptoms of pain, joint stiffness, and diminished physical function were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). After six weeks of treatment, responder analysis showed significant improvement in WOMAC scores across all parameters comparable to the paracetamol group, with 18% of the BCM-95 group reporting 50% improvement, and 3% of subjects noting 70% improvement.

BCM-95’s unique fusion of curcuminoids and turmerone-rich essential oil components overcomes curcumin’s characteristic bioavailability hurdles due to its inherent high lipophilic nature.

Results of a new study published in the journal Biomed Central BMC showed turmeric extract was as effective as paracetamol in reducing pain and other symptoms of knee osteoarthritis (OA). The study demonstrated the bioavailable compound was more effective in reducing inflammation.

“We are learning more about the mechanisms behind curcumin’s anti-inflammatory effect which we believe is a result of its ability to inhibit pro-inflammatory signals, such as prostaglandins, leukotrienes, and cyclooxygenase-2. In addition, curcumin has been demonstrated to suppress several pro-inflammatory cytokines and mediators of their release, such as tumor necrosis factor-α (TNF-α), IL-1, IL-8, and nitric oxide synthase,”said Antony.