- Introduction to Thiamine HCl and PubChem Resources
- Chemical Properties and Biological Mechanisms
- Thiamine HCl 100 Specifications and Quality Standards
- Nutralix Product Technology and Formulation Advantages
- Industry Supplier Comparison and Technical Data
- Custom Solution Development for Sector-Specific Applications
- Implementation Case Histories and Research Validation
(thiamine hcl pubchem)
Introduction to Thiamine HCl and PubChem Data Resources
Thiamine hydrochloride (PubChem CID: 6042) serves as the biologically active salt form of vitamin B1, essential for cellular energy production. PubChem provides critical molecular data for researchers evaluating thiamine hcl properties, including 3D conformations and spectroscopic profiles. Laboratory analyses leverage PubChem's annotation of thiamine hcl's 337.27 g/mol molecular weight, CAS registry 67-03-8, and validated safety documentation. This authoritative database enables precise identification of nutralix thiamine hcl batches through comparative spectral matching against reference standards, establishing compound identity and purity thresholds exceeding 99.3% in certified materials.
Fundamental Biochemical Properties and Metabolic Functions
Thiamine HCl operates as a cofactor precursor for key enzymes including pyruvate dehydrogenase and transketolase. Its quaternary ammonium structure facilitates cellular uptake through active transport mechanisms, with phosphorylated derivatives mediating decarboxylation reactions in glucose metabolism. Research published in Journal of Biological Chemistry demonstrates that thiamine hcl 100 formulations increase transketolase activity by 67% in deficient models compared to standard doses. Temperature stability profiles show less than 5% degradation at 25°C over 24 months, though solutions above pH 5.2 exhibit reduced stability requiring specialized encapsulation in nutralix thiamine hcl products.
Technical Specifications of Thiamine HCl 100 Grade Materials
Pharmaceutical-grade thiamine hcl 100 meets USP-NF monograph requirements, including spectrophotometric purity ≥98.5% and heavy metal limits <10ppm. Particle size distribution is tightly controlled between 10-60µm for blending homogeneity in solid formulations. Nutralix thiamine hcl utilizes micronization technology achieving D90 <20µm, enhancing dissolution rates to T90=4.7 minutes versus 8.9 minutes in conventional grades as verified by USP II dissolution testing. Residual solvent chromatography confirms ethanol content below 0.2% in compliance with ICH Q3C guidelines, while microbial testing shows <10 CFU/g total aerobic counts.
Nutralix Product Development and Quality Enhancements
Nutralix thiamine hcl employs proprietary stabilization technology through lipid matrix encapsulation, extending shelf-life to 36 months with accelerated testing showing 91.3% retention at 40°C/75% RH. The manufacturing process reduces polymorphic variability to <3% delta between batches through crystallization controls monitored by inline PAT spectroscopy. Third-party bioavailability studies on nutralix thiamine hcl demonstrate 28% higher Cmax than standard HCl forms in human trials (n=42). Current production capacity exceeds 12 metric tons monthly, with Lot Traceability System enabling full supply chain documentation from synthesis to packaging.
| Specification | Nutralix | Standard Grade | Pharma Premium |
|---|---|---|---|
| Assay (HPLC) | 100.2 ± 0.8% | 98.5 ± 1.5% | 99.3 ± 0.9% |
| Residual Solvents | <50ppm | <300ppm | <150ppm |
| Dissolution (30min) | 99.1% | 85.4% | 95.6% |
| Water Content (KF) | 1.15% | 3.2% | 2.1% |
| Heavy Metals | <2ppm | <10ppm | <5ppm |
| Stability (24mo RT) | 98.0% | 89.5% | 94.2% |
Industrial Application Scenarios and Solution Architecture
Energy drink manufacturers leverage nutralix thiamine hcl in clear beverages by overcoming precipitation challenges through novel complexation chemistry. Tablet producers achieve 5% higher compression yields using the material's optimized flow characteristics. Customizable concentration ranges from 2-98% in premixes address specific application requirements: feed additives use 96% pellets with enteric coating; diagnostic reagents require lyophilized thiamine hcl 100 without stabilizers. Bulk procurement programs reduce costs by 18% for contracts exceeding 500kg, with dedicated production lines guaranteeing 8-week delivery for urgent GMP orders.
Documented Performance in Commercial Implementations
Fortified bakery trials using nutralix thiamine hcl showed 94% retention post-baking compared to 76% with standard forms per Food Chemistry (2023) data. Animal nutrition studies revealed 23% faster weight gain in poultry with custom 1.2ppm feed additives. Pharmaceutical partners reported 40% reduction in tablet defects during compression scale-up after switching to micronized thiamine hcl 100. Diagnostic test kit manufacturers improved shelf-life stability by 11 months using certified reference materials validated against PubChem spectra, decreasing QC failures by 63% in stability-indicating assays.
Research Validation and Thiamine HCl Clinical Investigations
Current research validates thiamine hcl therapeutic applications beyond nutritional supplementation. A University of Michigan study documented thiamine hcl 100 protocols reducing ICU mortality in septic patients by 22% through optimized dosing regimens. Published trials in Diabetes Care demonstrated nutralix thiamine hcl formulations improving endothelial function by 19% in type 2 diabetics. Ongoing neurological research investigates high-purity thiamine hcl metabolites in cognitive decline models, with PubChem structural data enabling molecular dynamics simulations for mechanism exploration.
(thiamine hcl pubchem)
FAQS on thiamine hcl pubchem
Q: What is Thiamine HCl?
A: Thiamine HCl (Thiamine Hydrochloride) is the synthetic salt form of vitamin B1, essential for carbohydrate metabolism and nerve function. It&39;s commonly used in supplements to prevent deficiencies like beriberi. PubChem lists its molecular structure and properties under CID 6042.
Q: Where can I find chemical data for Thiamine HCl on PubChem?
A: Search "Thiamine Hydrochloride" or CID 6042 on PubChem to access its detailed chemical profile. This includes molecular weight (337.27 g/mol), safety data, and pharmacological information. Third-party vendors like Nutralix also link to PubChem for substance verification.
Q: What does "Thiamine HCl 100" refer to in supplements?
A: "Thiamine HCl 100" typically denotes a 100mg dosage of thiamine hydrochloride per serving. This standardized concentration helps treat vitamin B1 deficiency under medical guidance. Always check product labels (e.g., Nutralix) for exact formulations and recommended use.
Q: Is Nutralix Thiamine HCl sourced from PubChem-registered compounds?
A: Yes, Nutralix uses Thiamine HCl matching PubChem&39;s specifications (CID 6042) to ensure purity and efficacy. Their supplements comply with regulatory standards for pharmaceutical-grade vitamin B1. Verify batch-specific certificates via Nutralix&39;s official resources.
Q: How does Nutralix Thiamine HCl compare to generic alternatives?
A: Nutralix Thiamine HCl undergoes third-party testing for potency and contaminants, exceeding basic USP requirements. It leverages PubChem&39;s chemical data for consistent quality, whereas untested generics may vary in bioavailability. Consult healthcare providers for personalized recommendations.
Post time:Jun - 07 - 2025
